Comparative Study on Anesthetic Potency: RESULTS

In: Dental treatment

2 Feb 2010

The results are summarized in Tables 1 and 2 and Figure 3.

Comparison of the ED50 Values

When the potency of the test anesthetics was compared, we found that the A6 group compared with the L group showed a 2.8 times potency 5 and 10 minutes after administration. The ED50 of the A12 group was the lowest for all test anesthetics throughout the entire course, with a 3.6-4.2 times potency over the L group. The potency of the A12 group at its peak difference at the 15-minute measurement was 3.8 times that of the A6 group. The ED50 of the P group was higher compared with the other 3 groups, with the P group showing a 0.5-0.9 times potency over the L group.

Table 1. Effectivity of Each Local Anesthetic*

2 3 5 10 12 15 20 (min)
Lidocaine
0.1 ml (0/5) 0% (0/5) 0 (0/5) 0 (0/5) 0 (0/5) 0
0.15 (1/5) 20 (1/5) 20 (1/5) 20 (1/5) 20 (1/5) 20 (0/5) 0
0.2 (2/5) 40 (2/5) 40 (2/5) 40 (1/5) 20 (0/5) 0
0.25 (3/5) 60 (4/5) 80 (5/5) 100 (5/5) 100 (4/5) 80 (1/5) 20 (0/5) 0
0.3 (4/5) 80 (4/5) 80 (5/5) 100 (5/5) 100 (5/5) 100 (4/5) 80 (4/5) 80
0.4 (5/5) 100 (5/5) 100 (5/5) 100 (5/5) 100
0.5 (5/5) 100
Propotocaine
0.15 ml (0/5) 0 (0/5 0 (0/5) 0 (0/5) 0
0.2 (1/5) 20 (1/5) 20 (1/5) 20 (1/5) 20 (0/5) 0
0.25 (0/4) 0% (3/5) 60 (1/5) 20 (0/5) 0 (0/4) 0
0.3 (0/4) 0 (2/5) 40 (3/5) 60 (5/5) 100 (4/5) 80 (2/5) 40 (0/4) 0
0.4 (2/4) 50 (3/5) 75 (4/5) 80 (5/5) 100 (5/5) 100 (5/5) 100 (4/4) 100
0.5 (3/4) 75 (3/5) 75 (5/5) 100 (5/5) 100 (4/4) 100
Articaine
0.025 ml (0/5) 0
0.03 (0/5) 0 (0/5) 0
0.04 (0/5) 0% (0/5) 0 (0/5) 0 (0/5) 0
0.05 (1/5) 20 (2/5) 40 (2/5) 40 (1/5) 20
0.08 (2/5) 40 (3/5) 60 (3/5) 60 (3/5) 60 (3/5) 60
0.1 (2/5) 40 (4/5) 80 (5/5) 100 (5/5) 100 (5/5) 100 (0/5) 0
0.18 (4/5) 80 (5/5) 100 (5/5) 100 (2/5) 40 (0/5) 0
0.2 (3/5) 60 (1/5) 20
0.3 (5/5) 100 (4/5) 80 (2/5) 40
0.4 (5/5) 100 (4/5) 80
0.5 (5/5) 100
Articaine
0.025 ml (0/5) 0 (0/5) 0
0.03 (0/5) 0% (0/5) 0 (0/5) 0 (0/5) 0 (0/5) 0 (0/5) 0
0.04 (0/5) 0 (0/5) 0 (2/5) 40 (3/5) 60 (0/5) 0 (1/5) 20 (0/5) 0
0.05 (4/5) 80 (4/5) 80 (5/5) 100 (5/5) 100 (2/5) 40 (1/5) 20 (1/5) 20
0.08 (5/5) 100 (5/5) 100 (5/5) 100 (5/5) 100 (2/5) 40 (3/5) 60 (3/5) 60
0.1 (5/5) 100 (5/5) 100 (5/5) 100 (5/5) 100 (4/5) 80
0.18 (5/5) 100
* Effectivity was determined according to loss of reflex EMG upon electrical pulp stimulation after local anesthetic administration; effectivity is number of rabbits with loss of jaw-opening reflex/total number of rabbits.

Change in the ED50 Value Over Time

The difference in the ED50 value of the A6 group was greatest at the 2- and 3-minute measurements, and this difference was statistically significant compared with the other measurement stages. The A6 group showed values similar to those of the L group at the 20-minute postadministration measurement point. The ED50 of the L group was fairly stable up to the 12-minute measurement; however, it increased thereafter. The 2-, 3-, and 5-minute measurements of the P group were significantly higher compared with the other measurement stages. There was practically no change over time identified in the measurement stages of the A12 group. The pattern of changes in the ED95 value was similar to that seen in the ED50 value. canada viagra online

Figure 3. Comparison of the ED50 and ED95

Figure 3. Comparison of the ED50 and ED95 values of local anesthetics at various observation stages (where ED95 is top and ED50 is bottom of the bar graph). (1) P group, (2) L group, (3) A6 group, (4) A12 group.

Table 2. ED50 and ED95 Values of Local Anesthetics at Various Observation Stages*

Time (minutes) Lidocaine Propitocaine Articaine Articaine
ED50
2 0.22 (0.19-0.25) 0.43 (0.34-4.39) 0.11 (0.09-0.15) 0.05 (0.03-0.09)
CO 0.21 (0.18-0.24) 0.34 (0.26-0.56) 0.07 (0.07-0.08) 0.05 (0.03-0.09)
5 0.18 (0.15-0.22) 0.25 (0.23-0.27) 0.06 (0.05-0.11) 0.04 (0.03-0.08)
10 0.18(0.15-0.22) 0.24 (0.19-0.28) 0.06(0.05-0.11) 0.05 (0.04-0.06)
12 0.19 (0.17-0.22) 0.26 (0.23-0.3) 0.1 (0.09-0.11) 0.05 (0.04-0.07)
15 0.26 (0.23-0.3) 0.32 (0.26-0.42) 0.21 (0.18-0.24) 0.06(0.04-0.11)
20 0.31 (0.21-0.46) 0.36 (0-t) 0.3 (0.23-0.41) 0.08(0.06-0.11)
ED95
2 0.35 (0.3-0.46) 0.58 (0.48-t) 0.23 (0.17-0.36) 0.08 (0.06-0.25)
CO 0.34 (0.29-0.43) 0.62 (0.43-t) 0.14 (0.12-0.16) 0.08 (0.06-0.25)
5 0.25 (0.21-0.37) 0.35 (0.32-0.39) 0.1 (0.07-0.3) 0.06 (0.04-0.28)
10 0.25 (0.21-0.37) 0.32 (0.27-0.46) 0.1 (0.07-0.3) 0.07 (0.06-0.12)
12 0.28 (0.24-0.37) 0.36 (0.31-0.49) 0.16 (0.14-0.18) 0.08 (0.06-0.12)
15 0.36 (0.31-0.49) 0.42 (0.34-0.69) 0.34 (0.28-0.45) 0.1 (0.07-0.48)
20 0.4 (0.32-t) 0.42 (0-t) 0.45 (0.35-0.9) 0.14(0.11-0.23)
* The figures in parentheses indicate the confidence limits (upper/lower). When the confidence limit is °° according to the computation, then the upper limit is represented with t and the lower limit with 0. (The values are rounded off to 2 decimal points).

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