Colorectal polyposis and immune-based therapies: CYTOKINES AS IMMUNE MEDIATORS (Part 5)

In: Colorectal polyposis

3 Sep 2012

Increases in TGF-P1 stimulate the recruitment of tumour-infiltrating lymphocytes to the neoplastic site and cause a direct inhibitory effect of rat TNF-a and IL-10 on tumour proliferation in vitro. These seemingly contradictory findings on the role of TGF-P may be explained by a clear site dependency and biphasic mechanism of action. TGF-P levels are lowest in the rectum and highest in the ascending colon. Low levels of TGF-P are associated with the development of adenoma and support the higher epidemiologic incidence of colon neoplasia in the distal colon.

Cytokines that have been less well characterized in the context of a cell-mediated immune response to tumourigenicity are IL-4, IL-13, IL-1 and IL-8. IL-4 and IL-13 are structurally similar molecules that are produced by TH2 cells in response to antigen receptor binding. They may be induced by mast cells or basophils and the cytokines have commonly been associated with allergy, the humoral response and autoimmunity. The main role of IL-4 is to regulate TH2 development, whereas IL-13 mainly regulates mucus secretion and inflammation of the bowel . IL-1 is known to regulate the proliferation and differentiation of normal and malignant immune cells and also to play a role in angiogenesis and cellular growth. IL-1 promotes the adhesion of cancer cells to the endothelial lining of blood vessels and induces the expression of matrix metallo-proteinases in several cell types. IL-1 has been implicated in the progression of several malignancies, including cancer of the liver, lung and bone marrow . IL-8 is a cytokine with chemotactic properties that is able to induce respiratory burst, and promote angiogenic effects, degranulation, and enzyme release in neutrophils. Spend less money now – buy flovent inhaler for your efficient drug to cost less.


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