Circadian Influence in Cardiovascular Disease (Part 4)

In: Cardiovascular Disease

30 Nov 2012

Circadian Influence in Cardiovascular Disease (Part 4)Similar studies have also shown that the episodes of ischemic ST changes are often prolonged, asymptomatic, and frequently associated with nonexertional, nonstressful, routine activities. These findings taken collectively offer support to the concept of an enhanced vasomotor coronary tone associated with awakening/rising. ventolin inhalers
Two major studies on the cyclic variation of the incidence of acute myocardial infarction and sudden cardiac death have demonstrated a remarkably similar circadian periodicity. The incidence of both cardiac disorders was maximal during the morning hours, ie, 6 am to 12 noon. Although data concerning time of awakening in the populations studied were not available, it was suggested that recalculation of the hourly frequencies of such morbid events related to waking time would likely yield a more prominent circadian rhythm.
In the acute myocardial infarction study group, (a byproduct of the original multicenter investigation of limitation of infarct size [MILIS] study), this salient circadian variation was consistently observed in various population subgroups and showed no difference related to age, history of coronary artery disease, cigarette smoking, or coffee ingestion. After further analysis of their database the investigators made two important collateral observations: the 24-hour periodicity was not present in patients whose myocardial infarction began on Saturday or Sunday, nor was it present when they were taking p-blockers in the 24 hours before the onset of myocardial infarction.


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