Cellular Nutrition in Support of Early Multiple Organ Failure (9)

In: Cellular Nutrition

3 Jun 2013

Cellular Nutrition in Support of Early Multiple Organ Failure (9)Amino Acids in Cellular Nutrition
There is also evidence that amino acids can serve as more than simply the substrate for endogenous tissue repair and protein synthesis: they can also influence the immune system. Arginine has received increasing attention as an immune modulator. The immunomodulatory property is probably related to its function as a lymphotropic agent and a stimulator of pituitary growth hormone and insulin. In cancer patients undergoing major surgery, supplementation with arginine, 25 g/d, improved nitrogen balance and enhanced the T-lymphocyte stimulation index.

Leiberman et al also reported an improved nitrogen balance and immune function following an arginine-rich enteral (IMPACTâ„¢) regimen in cancer patients. The immunoenhancing effects are illustrated by arginine s ability to increase allograft rejection and to lead to tumor regression. Molecular biology studies have identified L-arginine as the likely precursor for the synthesis of EDRFs. Indeed, Ignarro et al have demonstrated that L-arginine depletion diminishes endothelium-dependent vasorelaxation of the bovine pulmonary artery or vein. Amino acids may also play an important role when the gut mucosal barrier suffers endothelial damage, which leads to bacterial translocation.

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