A 60% reduction in baseline LTB4 production in leukocytes was demonstrated in rabbits after a 10-g fish oil infusion. Hence, incorporation of fish oil into a labile lipid pool by low-dose continuous infusion may be as effective as longterm administration in manipulating eicosanoid synthesis. Indeed, we have shown that parenteral administration of fish oil to experimental animals with either burns27 or endotoxemia28 improved energy expenditure, nitrogen balance, and metabolic responses.
The facilitation of the release of EDRFs by co-3 PUFAs can explain their antithrombotic and antiatherosclerotic effect, as EDRF release not only relaxes vascular smooth muscle but also inhibits platelet adhesion and aggregation. Evidence from animal studies suggests that endothelin-induced bronchoconstriction, coronary vasoconstriction, and hypertension are associated with endothelins ability to activate phospholipase A, and thereby stimulate the production of arachidonate metabolites.30 Clearly, both EDRF- and endothelin-induced cellular actions can be modified by the concomitant release of prostaglandins with the use of a u>-3 PUFA-enriched diet.
In addition to PGI3 helping perfusion by vasodilatory effects, decreased TXA, by fish oil may reduce the release of oxygen free radicals by polymorphonuclear leukocytes, a thromboxane-dependent event.
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