Blood pressure, heart rate, hematocrit, CVI? ECG, urine output, and blood gases are conventional measurements that are well recognized descriptors of acute crises as well as the end stages of circulatory failure. Although these variables should be monitored and corrected if abnormal, they are neither sensitive nor accurate descriptors of circulatory decompensation in the perioperative […]
The cardiac output, Do2 and Vo2 values were higher in the protocol patients than in the control patients, while the other monitored variables were not appreciably different, indicating that there was reasonable compliance with the protocol. The higher Cl and Do2 values are consistent with the concept that this pattern represents compensatory increases in circulatory […]
Complications were observed less frequently in patients treated by the protocol in both series (Table 8). Both the proportion of patients who had complications and the average number of complications per patient were lowest in the PA-protocol group (p<0.05). There was a higher incidence of patients with multiple complications in the control group of both […]
Outcome Data Table 6 summarizes the outcome data of the control and protocol groups of the first series which had sufficient numbers of patients to stratify into clinical subgroups. There were 168 operations on 151 control patients, 57 (38 percent) of whom died and 108 operations on 101 protocol patients, 21 (21 percent) of whom […]
Statistical Methods Comparisons of mortality and morbidity figures were done using chi square analysis with Yates’ correction for small cell size where applicable. Hemodynamic data comparisons within groups and between groups were analyzed using either paired or unpaired Student’s t test and ANO\A with Newman-Keuls’ test for significance of individual comparisons. All p values were […]
Physiologic Methods Flow-directed, balloon-tipped PA catheters were placed percutaneously in study patients via an internal jugular or subclavian vein, and radial arterial catheters were put in place in the ICU before preoperative medication. Pulmonary arterial pressures, HE, MAE CV£ and pulmonary capillary WP were measured. Cardiac output then was measured by thermodilution using a cardiac […]
Experimental Design In series 1, patients were prospectively allocated to either a protocol or control service. One or two of the three adult general surgical services were prospectively designated as control services and the other one or two services as the protocol service according to a prearranged schedule developed prior to the beginning of each […]
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