This activity may be a somewhat different molecular weight than depressant molecules that have been previously described. This difference may be due to the fact that the myocyte system in the present study is capable of assessing in vitro myocardial cell performance using unmodified serum. Previous studies analyzing the properties of cardiodepressant substances have used […]
The in vitro myocardial cell contractility assay employed in this study represented a modification of a previously described cell culture system.’ The addition of the latex microspheres improved the reliability of the system. Using this revised method, the amount of depression can be quantified reproducibly. Since the sensitivity of the cell culture system changes as […]
In addition to cardiovascular function, this study investigates a possible association between MDS posi-tivity and a variety of laboratory parameters and measures of organ function. The only laboratory parameter that distinguished between patients with and without MDS was a significantly higher mean peak lactic acid level in the group with MDS. Several possible pathophysiologic mechanisms […]
A previous study excluded the possibility that myocardial depression resulted from electrolyte abnormalities or from circulating pharmacologic agents. The methods used to exclude electrolyte abnormalities or pharmacologic agents as causes of myocardial cell depression can be summarized as follows: (1) control groups receiving identical medications and having similar electrolyte derangements failed to show any myocardial […]
Further, this in vivo myocardial depression was correlated significantly with the extent of myocardial cell shortening observed using an in vitro model of myocardial cell performance. This correlation suggests that the degree of in vitro myocardial cell depression reflects the pathophysiologic events responsible for the in vivo myocardial depression. These findings confirm and extend the […]
Correlation of Ejection Fraction with Extent of Myocardial Cell Shortening Figure 3 illustrates the relationship between the radionuclide determined in vivo EF (days 2 to 4) and the in vitro percentage of change in extent of myocardial cell shortening in the 14 septic shock patients with MDS. As mentioned above, a positive assay for MDS […]
Analysis of Factors that Can Influence Ejection Fraction Although EF is used as a measure of cardiac performance, it can be altered by changes in preload, afterload, and heart rate. The PAWP and EDVI can be used as measures of LV preload. Both were significantly higher in patients with MDS, even though the mean EF […]
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