Although no change in BP was found after 2 weeks of MPA, there was a significant decrease of the systolic BP at the 3-week washout. This finding was not expected and there is a high likelihood of a random observation; however, cardiovascular effects have been monitored during MPA therapy with controversial results, but to our […]
The prolonged effect of MPA observed in the present study could also be explained by the fact that we, unlike most others, only included female patients. Although progesterone and estrogen levels in postmenopausal women correspond to those of men, there is a marked difference in serum LH and FSH concentrations. Hormone replacement therapy is therefore […]
Our results in women with chronic respiratory failure provide evidence that a significant proportion of the improvement of gas exchange achieved with the 14-day MPA therapy is maintained beyond 3 weeks after cessation of the hormone therapy. This high-dose of MPA was also well tolerated by postmenopausal women. These results warrant further studies into the […]
Sustained Effects of MPA The blood gases were reevaluated after 3- and 6-week washout periods. At the 3-week washout, PaC02 and Pa02 values remained improved in 11 and 8 patients, respectively. At 3 weeks after cessation of MPA, the mean PaC02 was still 3.0 mm Hg (95% CI, 0.75 to 4.5) or 6.1% (95% CI, 2.3 to 9.9; […]
Thirteen of 14 patients completed the trial. One subject discontinued because of fever and viral respiratory tract infection after her second visit, Serum creatinine, WBC count, prolactin, estradiol, progesterone, TSH, SHBG, LH, and FSH were in the normal range at baseline, and serum lipids were within the inclusion criteria, One subject had mild anemia (hemoglobin, […]
Laboratory Assays Blood hemoglobin concentration, hematocrit, and WBC count were measured with appropriate laboratory apparatus (Coulter STKR; Coulter Corp; Hialeah, FL). Serum creatinine was determined with the Jaffe method (catalog number 1730304; Boehr-inger Mannheim Systems; Mannheim, Germany); alanine aminotransferase, total cholesterol, and triglycerides with enzymatic methods (Hitachi 717; Hitachi; Tokyo, Japan); and high-density lipoprotein with […]
Study Design The 12-week study was a placebo-controlled single-blind trial. Seven days after the baseline measurements, all patients started with placebo treatment for 14 days. The placebo measurements were made in the morning after the last evening placebo dose. After a 7-day interval, MPA treatment for 14 days was started, and the MPA measurements were […]
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