Archive for the ‘Respiratory’ Category

Respiratory Insufficiency in Postmenopausal Women: ConclusionAlthough no change in BP was found after 2 weeks of MPA, there was a significant decrease of the systolic BP at the 3-week washout. This finding was not expected and there is a high likelihood of a random observation; however, cardiovascular effects […]

The prolonged effect of MPA observed in the present study could also be explained by the fact that we, unlike most others, only included female patients. Although progesterone and estrogen levels in postmenopausal women correspond to those of men, there is a marked difference in serum LH and FSH concentrations. Hormone replacement therapy is therefore likely to have a much more complex and interactive role with trophic effects in women. […]

Respiratory Insufficiency in Postmenopausal Women: DiscussionOur results in women with chronic respiratory failure provide evidence that a significant proportion of the improvement of gas exchange achieved with the 14-day MPA therapy is maintained beyond 3 weeks after cessation of the hormone therapy. This high-dose of MPA was also well tolerated by postmenopausal women. These results warrant […]

Sustained Effects of MPA
The blood gases were reevaluated after 3- and 6-week washout periods. At the 3-week washout, PaC02 and Pa02 values remained improved in 11 and 8 patients, respectively. At 3 weeks after cessation of MPA, the mean PaC02 was still 3.0 mm Hg (95% CI, 0.75 to 4.5) or 6.1% (95% CI, 2.3 to 9.9; Fig 3) lower than baseline, whereas at 6 weeks the mean PaC02 had returned to […]

Respiratory Insufficiency in Postmenopausal Women: ResultsThirteen of 14 patients completed the trial. One subject discontinued because of fever and viral respiratory tract infection after her second visit, Serum creatinine, WBC count, prolactin, estradiol, progesterone, TSH, SHBG, LH, and FSH were in the normal range at baseline, and serum lipids were within the inclusion criteria, One subject had […]

Laboratory Assays
Blood hemoglobin concentration, hematocrit, and WBC count were measured with appropriate laboratory apparatus (Coulter STKR; Coulter Corp; Hialeah, FL). Serum creatinine was determined with the Jaffe method (catalog number 1730304; Boehr-inger Mannheim Systems; Mannheim, Germany); alanine aminotransferase, total cholesterol, and triglycerides with enzymatic methods (Hitachi 717; Hitachi; Tokyo, Japan); and high-density lipoprotein with PEG-precipitation and an enzymatic method (Hitachi 717; Hitachi). Estradiol and progesterone were measured with […]

Respiratory Insufficiency in Postmenopausal Women: Study DesignStudy Design
The 12-week study was a placebo-controlled single-blind trial. Seven days after the baseline measurements, all patients started with placebo treatment for 14 days. The placebo measurements were made in the morning after the last evening placebo dose. After a 7-day interval, MPA treatment for 14 days was […]

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Blog invites submissions of review articles, reports on clinical techniques, case reports, conference summaries, and articles of opinion pertinent to the control of pain and anxiety in dentistry.