Anticholinergic ADEs are common with trospium (Table 4). More than half of the patients in the clinical trials experienced one or more ADEs. The most commonly reported ADEs were dry mouth, constipation, abdominal pain (upper), constipation (aggravated), headache, and fatigue.

Trospium chloride is a quaternary amine that antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs. It exhibits parasympatholytic action by reducing the detrusor tone of smooth muscle in the bladder as well as uncontrolled detrusor contractions that can cause OAB with incontinence.