C. “Natural killer cell” antigens: In 1984 Ruff and Pert reported the presence of reactive sites on SCLC shared by specific markers for macrophages. They suggested a hemopoietic stem cell origin for SCLC. Later, the expression of certain natural killer cell antigens such as Leu-725 and NKH-l were identified. Leu-7 was demonstrated in 16/20 SCLC […]
B. Specific peptides: Multiple peptides have been demonstrated in SCLC tumors based on immunohistochemistry. At present the literature is loaded with studies using different antibodies, which hampers an interpretation of the results. Bombesin or the mammalian homologue, gastrin-releasing peptide (GRP), has attracted considerable interest. It acts apparently as an autocrine growth factor for SCLC, and […]
Immunohistochemistry It has been known for decades that SCLC has a great potential for producing multiple endocrine “markers.” Following the rapid development in immunocytochemistry and monoclonal antibodies during the past decade, much interest has been devoted to a variety of malignant lung tumors including SCLC. The studies have particularly concentrated on the following subjects: (A) […]
Small cell lung cancer (SCLC) has emerged over the last 10-15 years as a distinct pathologic and clinical entity, characterized by early and wide dissemination and with a great sensitivity to both chemotherapy and radiotherapy. Despite the objective response to chemotherapy in more than 85%, most of the patients sooner or later develop clinical relapse, […]
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