Only one patient in this series had evidence of a primary viral pneumonia (prevalence 16.7 percent; 95 percent confidence intervals, 0 to 46.5 percent). Studies in athymic mice suggest that the T-cell response may actually enhance parenchymal inflammation, so that deficient cellular immunity in HIV-infected hosts may in fact protect against early pulmonary abnormalities. A […]
Prolonged respiratory illness was present in four of six HIV-infected patients in this series, despite the rarity of advanced HIV infection in the sample. No serial virologic assessment of respiratory tract shedding was performed, yet previous studies have demonstrated a close correlation of the duration of fever with length of viral shedding. In this series, […]
Although the prevalence of influenza in the 1988-1989 season, the virulence of predominant virus strains during this interval, and the lack of advanced immunosuppression in our cohort are variables that have not been controlled for, our findings agree with those findings of the scant published literature to date. No increased incidence or alteration in clinical […]
We describe six patients with HIV infection in whom influenza virus was isolated from induced sputum or BAL specimens at SFGH between December 1988 and March 1989. The patients comprising this report were sufficiently ill to warrant evaluation for P carinii pneumonia. Therefore, we believe that they represent the most severely ill HIV-infected patients seen […]
Influenza B was later isolated from both the admission sputum and broncho-scopic specimens. The pathologic specimen showed focal chronic inflammation and fibrosis with increased numbers of macrophages. The patient was discharged after nine days of hospitalization with a diagnosis of “bacterial versus viral pneumonia.” At the time of follow-up 14 days later, he denied residual […]
In five patients, chest roentgenograms showed increased interstitial markings bilaterally; however, most were without acute change when compared with prior or later roentgenograms. One patient had a chest roentgenogram abnormality believed to represent an acute viral pneumonia (Fig 2); the course of illness in this patient is summarized as follows: A 42-year-old gay male smoker with […]
Review of the medical record indicated that none of the patients had received influenza vaccine in the 1988-1989 season. No patients were receiving zidovudine or other antiviral medications at the time of initial clinical examination. Symptoms of fever and/or cough began a median of six days (range, 2 to 21 days) before the patients came […]
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