The findings of this investigation allow us to make two important clinical observations. First, as in other reports, our results allude to the higher elucidation of TNFa in patients with chronic heart failure, even in the absence of cachexia. Second, and more importantly, we were unable to demonstrate a significant improvement in elaboration of TNFa […]
TNFa in CHF Patients and Control Subjects The mean concentration of TNFa in the normal control subjects was 0.89±0.40 pg/mL (range, 0.5 to 9.7 pg/mL) and was above the limit of detection (>0.5 pg/mL) in 8 subjects. Plasma concentrations of TNFa in acutely decompensated CHF patients were significantly higher (p<0.002) at 3.0±0.4 pg/mL (range, 0.5 […]
Study Population The study population consisted of 29 noncachectic patients (20 men and 9 women; age range, 27 to 79 years; mean 56 ±13 years) with advanced CHF who demonstrated acute decompensation while receiving adequate oral medical therapy, thus requiring admission to the hospital for therapeutic intervention. Patients were excluded if they exhibited any evidence […]
Study objective: To evaluate the clinical relevance of circulating tumor necrosis factor-a (TNFa) in subjects with advanced acutely decompensated congestive heart failure (CHF) and to determine the modulatory effect of clinical interventions on short-term elaboration of this cytokine. Design: Prospective, case-controlled study. Setting: Inpatient and outpatient (hospital and clinic), at regional academic medical center. Patient […]
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