DISCUSSION
Ketamine has been used as an oral sedative in the management of uncooperative patients. Common side effects of ketamine are nausea and vomiting, which have been reported in 0-43% of patients. In this study, the addition of promethazine, a potent antiemetic drug, reduced the vomiting incidence from 27% (control group) to 0% (experimental group).

The age range of the subjects was 21-43 months, with a mean age of 33V2 months. There were no significant differences in age (for controls, range, 21-43 months; mean, 33 months; for experimental patients, range, 25-43 months; mean, 34 months) (Table 3). Under the conditions of this study, the average time in the operatory, from [...]

Pediatric dental patients from the Houston Medical Center Pediatric Dental Clinic, Houston, Tex, were chosen for the study, which was approved by the Committee for the Protection of Human Subjects. The selection cri­teria included healthy patients between IV2 and 3Vi years of age with no previous dental experience and those who demonstrated such poor behavior [...]

Ketamine is a dissociative anesthetic agent that has been shown to be useful as a safe and effective oral sedative. The drug was first derived in 1961, and reports on human trials were begun in 1965. It is a chemical derivative of phencyclidine and cyclohexami-ne. Ketamine is unique in being effective for induction of anesthesia [...]