A similar study with the natriuretic peptides derived […]
If the lungs are synthesizing and secreting a large amount of the N-terminus and C-terminus of the ANF prohormone in persons with congestive heart failure, it is possible that their nearly equal concentrations in the plasma and pleural fluid of patients with congestive heart failure is due to the lung producing a significant amount of the plasma concentration of both the N-terminus and C-terminus of the ANF prohormone, as well […]
A second possibility is that the whole ANF prohormone is being made in the lung and secreted directly into the pleural fluid. Pleural fluid originates from the lung rather than the pleura, and it is possible that both the N-terminus and C-terminus of the ANF prohormone are secreted simultaneously with this fluid into the pleural space. Now that the whole prohormone (ie, all 126 amino acids) has been found in […]
The etiology of the N-terminus of the ANF […]
The present investigation demonstrates that the whole N-terminus (ie, aa 1-98) of the 126 aa ANF prohormone is present in pleural fluid of patients with congestive heart failure. With the previous demonstration that the C-terminus (ie, ANF, aa 99-126) is present in pleural fluid, it is now evident that all 126 aa of the ANF prohormone are present in the pleural fluid of congestive heart failure patients. Whether the whole […]
The concentrations of immunoreactive pro ANF 198 (whole N-terminus) and ir pro ANF 31-67 (midportion of the N-terminus) in the pleural fluid of each of six individuals with New York Heart Association (NYHA) class 2 congestive heart failure are shown in Figure 1. The mean concentration of pro ANF 1-98 in the pleural fluid of these patients was 1631 ± 147 finol/ ml (SEM). The average concentration of pro ANF […]
The pro ANF 31-67 […]
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