Archive for the ‘Chemotherapy’ Category

Innovative Chemotherapy: Identification of New Chemotherapeutic AgentsIdentification of New Chemotherapeutic Agents
For the past 3 decades, the major strategies of preclinical testing of agents with potential anticancer activity in humans has depended on the use of mice bearing transplantable tumors (predominantly leukemias) of murine origin. This effort has utilized enormous resources of time, talent and money, and the results of screening several […]

Prospective Trial of Individualized Chemotherapy
While several thousand correlations have been performed between the results of in vitro testing and clinical response, relatively few properly conducted prospective clinical trials have been reported. Currently, we are more than halfivay through a prospective clinical trial based on selection of individualized therapy for patients with extensive stage SCLC.W This disease presents unusual problems as well as opportunities for such a trial. While […]

Innovative Chemotherapy: Investigation of the Multidrug Resistant PhenotypeInvestigation of the Multidrug Resistant Phenotype
Multidrug resistance is a common clinical problem in lung cancer. In SCLC, most tumors recurring after chemotherapy manifest this phenotype, while some demonstrate it prior to therapy. In contrast, most NSCLC and carcinoid tumors demonstrate de novo resistance. While there are many possible reasons for chemoresistance to multiple […]

We have focused on the semiautomatic MTT assay, a tetrazolium dye method. Large numbers of samples can be tested at many drug concentrations and the results obtained within a few days. The major disadvantage of such assays is that they are unable to discriminate between normal and tumor cells if applied to fresh tumor samples. We are attempting to adapt the assay for clinical use by combining it with short-term […]

Innovative Chemotherapy: In vitro Drug Sensitivity TestingIn vitro Drug Sensitivity Testing
Selection of individualized chemotherapy based on in vitro drug sensitivity testing (DST) has been a goal of clinicians for more than 3 decades. Despite intense interest and research, and the development of multiple assay methods, this goal has remained theoretic for the most part. In applying such procedures, the following points […]

The former results in higher take rates and rapid fatality. Of interest, the intracranial tumors selectively locate in meningeal and ventricular sites. Thus, it represents a useful model of meningeal carcinomatosis. While only a few tumors can be transplanted intraperito-neally, widespread dissemination may result, with frequent involvement of pleural and pericardial spaces. Thus, these inoculation routes may provide useful models for pleural and pericardial involvement. Other occasionally utilized sites include […]

Innovative ChemotherapyXenografts and In vitro Drug Sensitivity Testing
Over 150,000 cases of lung cancer occur in the USA annually, nearly 90% of whom will die of their disease with a median life expectancy of less than 1 year. Obviously, we need both new drugs as well as new therapeutic concepts. While the latter […]


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