Of 347 endomyocardial biopsies performed on 49 patients, 47 specimens demonstrated histologic evidence of acute rejection. In this study, acute rejection was characterized by the presence of interstitial edema with pyrinophilic lymphocytes, with or without myonecrosis. Simultaneous immune activation of peripheral blood lymphocytes occurred with 33 biopsy specimens positive for acute rejection (Table 1). Thus, […]
Acute cardiac rejection may be difficult to diagnose in orthotopic cardiac transplant patients. The endomyocardial biopsy is the current gold standard for detection of acute rejection. This study examined the feasibility of morphologic evaluation of peripheral blood lymphocytes to provide a sensitive indicator of acute cardiac rejection. Material and Methods Peripheral blood lymphocytes of 49 […]
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