Anesthetic Efficacy of a Combination of Hyaluronidase: RESULTS

Twenty-three males and 7 females from age 19 to 43 years (average 24 years) participated in this study. One hundred percent of the subjects had subjective lip and tongue anesthesia with the IAN blocks. The discomfort ratings of solution deposition for the IAN blocks are presented in Table 1. There were no significant differences (P > .05) between the solutions.

Figure 1. Incidence of second molar anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the 2 anesthetic solutions.
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Figure 2. Incidence of first molar anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the 2 anesthetic solutions.

Table 1. Percentages and Discomfort Ratings of Solution Deposition

Figure 3. Incidence of second premolar anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the 2 anesthetic solutions.

Anesthetic success is presented in Table 2. Success rates for the lidocaine solution ranged from 20 to 81%, and for the lidocaine solution with hyaluronidase success ranged from 23 to 70%. There were no significant differences (P > .05) between the two solutions. The incidence of pulpal anesthesia for the two techniques is presented in Figures 1 through 6.
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Figure 4. Incidence of first premolar anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the 2 anesthetic solutions.

Table 2. Percentages and Number of Subjects Who Experienced Anesthetic Success

The postoperative pain ratings and subjects reporting postoperative trismus are summarized in Table 3 and 4. The lidocaine solution with hyaluronidase had significantly (P < .05) higher pain ratings and percentage of patients reporting trismus.
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Figure 5. Incidence of lateral incisor anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the 2 anesthetic solutions.

Table 3. Percentages and Discomfort Ratings for Postinjection Survey

The pH of the solutions were 7.78 for buffered lidocaine with epinephrine and 7.86 for buffered lidocaine with epinephrine plus hyaluronidase.
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Figure 6. Incidence of central incisor anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the 2 anesthetic solutions.

Table 4. Percentage and Number of Subjects Reporting Postoperative Trismus