Allergic Response to Metabisulftte in Lidocaine Anesthetic Solution: RESULTS

The patient returned 24 hours later with a large 10-cm-long, 7-cm-wide raised wheal on the right forearm. It was red and itchy (Figures 4 and 5). The location of the reaction corresponded to the test dose of 2% lidocaine with 1:100,000 epinephrine. The anterior vestibule and soft tissue of the chin had mild/moderate edema as well. The other sites, ie, those of saline, mepivacaine, and lidocaine without epinephrine, showed no reaction.

Figures 4 and 5. Reaction in area of lidocaine with epinephrine and metabisulfite 24 hours after administration.
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