Less than 10% of the trospium dose is absorbed following oral administration; peak plasma concentrations (Cmax) are achieved five to six hours after a single dose. Exposure causes a decrease in the Cmax and an area-under-the-curve (AUC) concentration of up to 59% and 33%, respectively, for evening doses and morning doses. Because high-fat meals decrease [...]

INTRODUCTION Overactive bladder (OAB) is a symptom syndrome that refers to the layered, smooth muscle that surrounds the bladder, the detrusor muscle. This muscle contracts spastically, sometimes without a known cause, resulting in sustained, high bladder pressure and the urgent need to urinate. People with OAB often experience urgency at inconvenient and unpredictable times. This [...]