Tadalafil generic causes a variety of adverse reactions. Nearly all patients in the clinical trials experienced one or more adverse events. The most commonly reported adverse reactions were headache, dyspepsia, back pain, myalgia, nasal congestion, flushing, and painful limbs.

Treatment should begin with the least invasive therapies. Any drugs that might be contributing to ED should be discontinued. In the case of antihyperten-sive agents, other drugs with a different mechanism of action should be considered. Next, psychotherapy and behavior modifications might be considered, followed by oral drugs; locally injected drugs; vacuum devices; and, finally, [...]

The Padman-Nathan Study and Manufacturer’s Data
Tadalafil tablet was studied in the general ED population in seven randomized, multicenter, double-blind, placebo-controlled trials of 12 weeks’ duration. Two of the studies were conducted in the U.S., and five were conducted in centers outside the U.S.