Reactions
After removal of the patch, the site of application was examined to evaluate the area for signs of irritation. No tissue discoloration, swelling, or sloughing was noted in association with patch application in any of the patients. In addition, no drug-related adverse effects were associated with patch application. None of the patients experienced any complications, [...]

Although plasma levels of local anesthetic are usually low in adults, plasma concentrations can be an important concern in the delivery of local anesthetics to children. The dose as a proportion of total body weight in the adult is relatively small, and thus the chance of local anesthetic toxicity is low. However, in children, particularly [...]

This study was approved by the institutional review board of Columbus Children’s Hospital. Eligible subjects were selected from children scheduled for operative dentistry under general anesthesia at the Children’s Hospital Outpatient Surgery Center. These children had exhibited disruptive behaviors during routine dental appointments, thus requiring general anesthesia for comprehensive dental care. Eligible patients were those [...]

INTRODUCTION
Children most often associate pain during a dental visit with the administration of local anesthetic. Pain and discomfort perceived by pediatric patients can be severe. In a survey of 119 children, 65 thought that a “shot” or “needle” hurt more than anything else that had ever happened to them.